If you have played the original Marvel’s Spider-Man, you might remember there being several puzzles in the form of mini-games. This continues in a similar fashion in Spider-Man 2 where you encounter the antidote puzzle after taking Harry’s help for it. After getting Dr. Connors’s blood sample, you will need to take it to Harry and he will ask you to clear out the corrupted atoms within it.
So in this guide, we will show you exactly how you can solve this atom puzzle no matter which difficulty you are playing on.
Marvel’s Spider-Man 2 Antidote Puzzle Solution Guide

While the antidote atom puzzle in Marvel’s Spider-Man 2 may seem complicated at first glance, it is one of the easiest puzzles once you understand how it works.
Since the pattern and number of corrupted atoms can differ based on your difficulty settings, we are going to explain how to solve the puzzle rather than the exact solution for a given pattern.
Your goal here is to get rid of all the corrupted atoms indicated in the color red with spikes protruding out of them. You also have to make sure the essential atoms are not destroyed in the process. The essential atoms are indicated by the color green with rings around them.
Also Read: How To Analyze Black Cat’s Scratch Marks In Spider-Man 2
If you move your cursor and highlight a particular atom then press X, this will destroy that atom, easy right? Well here is the catch: any atom that you destroy also destroys the adjacent atoms connected to it.
You can check which atoms will get destroyed as they will increase in size when you hover over any given atom. That selected atom and the other atoms that will get destroyed in the process will all get bigger in size indicating that those are the ones that will be destroyed.

Take a look at the picture above, if you choose to destroy the corrupted atom on the left, it will also destroy the essential atom to its bottom left as it’s connected to it.
So instead, what you need to do is destroy the normal orange atom on the right side, these orange atoms are allowed to be destroyed and since it is connected to two corrupted atoms, it will destroy both of them while preserving the essential atom.
And so by applying this method, you need to clear out all the corrupted atoms to successfully have the solution for the pattern you are dealing with in Spider-Man 2’s antidote puzzle. Make sure to rotate around the pattern so you can get a clear view of all the connected atoms to the one you are destroying.
That is it for this guide on how to get the Marvel’s Spider-Man 2 antidote puzzle solution. Since you’ll be leveling up your character after completing this mission, you might also be interested in knowing about the best skills to unlock early in Marvel’s Spider-Man 2.